| Primary Identifier | MGI:5551323 | Allele Type | Targeted |
| Attribute String | Inducible, Recombinase | Gene | Gt(ROSA)26Sor |
| Transmission | Germline | Strain of Origin | (C57BL/6 x 129S4/SvJae)F1 |
| Induced With | tamoxifen | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | A fusion protein consisting of cre recombinase and the mutated ligand binding domain of the human estrogen receptor (ERT2) was inserted into intron 1. The estrogen receptor contains 3 mutations (G400V, M543A, L544A) that increase sensitivity to tamoxifen. Following oral administration of tamoxifen recombination efficiency varies from up to 50% to almost 100% depending on the target allele and tissue. Recombination was lowest in the brain. |
