| First Author | Cheng YT | Year | 2023 |
| Journal | Neuron | Volume | 111 |
| Issue | 8 | Pages | 1301-1315.e5 |
| PubMed ID | 36787749 | Mgi Jnum | J:350828 |
| Mgi Id | MGI:7448339 | Doi | 10.1016/j.neuron.2023.01.015 |
| Citation | Cheng YT, et al. (2023) Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits. Neuron |
| abstractText | Social experience is essential for the development and maintenance of higher-order brain function. Social deprivation results in a host of cognitive deficits, and cellular studies have largely focused on associated neuronal dysregulation; how astrocyte function is impacted by social deprivation is unknown. Here, we show that hippocampal astrocytes from juvenile mice subjected to social isolation exhibit increased Ca(2+) activity and global changes in gene expression. We found that the Ca(2+) channel TRPA1 is upregulated in astrocytes after social deprivation and astrocyte-specific deletion of TRPA1 reverses the physiological and cognitive deficits associated with social deprivation. Mechanistically, TRPA1 inhibition of hippocampal circuits is mediated by a parallel increase of astrocytic production and release of the inhibitory neurotransmitter GABA after social deprivation. Collectively, our studies reveal how astrocyte function is tuned to social experience and identifies a social-context-specific mechanism by which astrocytic TRPA1 and GABA coordinately suppress hippocampal circuit function. |
