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Allele : Tg(INS-HBEGF*L148S*P149T)70Rin transgene insertion 70, The Tokyo Metropolitan Institute of Medical Science
Primary Identifier  MGI:5565218 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(INS-HBEGF*L148S*P149T)70Rin
Strain of Origin  C.BKa-Prkdc<scid>/IcrJcl Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene consists of the 1.9 kb human insulin promoter region, rabbit beta-globin intron, human diphtheria toxin receptor (HBEGF) with L148S/P149T mutations, and the polyadenylation signals of rabbit beta-globin and SV40. It was injected into the pronucleus of Prkdcscid eggs. Transgene expression is seen in pancreatic beta cells and administration of diphtheria toxin results in HBEGF expressing cells.
  • mutations:
  • Insertion
  • synonyms:
  • INS-TRECK-Tg,
  • INS-TRECK-Tg,
  • Tg(INS-TRECK/DTR)1Rin,
  • Tg(INS-TRECK/DTR)1Rin
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