| Primary Identifier | MGI:5568072 | Allele Type | Targeted |
| Attribute String | Constitutively active | Gene | Gabbr2 |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A serine to alanine at amino acid 783 mutation was inserted into exon 16 and a floxed neo cassette was inserted in intron 16 via homologous recombination. Cre mediated recombination removed the neo cassette. The mutation in exon 16 eliminates a phosphorylation site. Absence of phosphorylation was confirmed by western blot analysis. Total GABBR2 protein expression was significantly increased in homozygous mice. |
