| First Author | Ferreira SA | Year | 2023 |
| Journal | NPJ Parkinsons Dis | Volume | 9 |
| Issue | 1 | Pages | 164 |
| PubMed ID | 38092806 | Mgi Jnum | J:344203 |
| Mgi Id | MGI:7572636 | Doi | 10.1038/s41531-023-00606-w |
| Citation | Ferreira SA, et al. (2023) Sex-dimorphic neuroprotective effect of CD163 in an alpha-synuclein mouse model of Parkinson's disease. NPJ Parkinsons Dis 9(1):164 |
| abstractText | Alpha-synuclein (alpha-syn) aggregation and immune activation represent hallmark pathological events in Parkinson's disease (PD). The PD-associated immune response encompasses both brain and peripheral immune cells, although little is known about the immune proteins relevant for such a response. We propose that the upregulation of CD163 observed in blood monocytes and in the responsive microglia in PD patients is a protective mechanism in the disease. To investigate this, we used the PD model based on intrastriatal injections of murine alpha-syn pre-formed fibrils in CD163 knockout (KO) mice and wild-type littermates. CD163KO females revealed an impaired and differential early immune response to alpha-syn pathology as revealed by immunohistochemical and transcriptomic analysis. After 6 months, CD163KO females showed an exacerbated immune response and alpha-syn pathology, which ultimately led to dopaminergic neurodegeneration of greater magnitude. These findings support a sex-dimorphic neuroprotective role for CD163 during alpha-syn-induced neurodegeneration. |
