Primary Identifier | MGI:5569532 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(CMV-HTT*89Q)ATag |
Strain of Origin | FVB/N | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The full-length human huntingtin cDNA containing 89 CAG repeats is under the control of the cytomegalovirus promoter and SV40 enhancer. Three lines, A-C, were established. No CAG repeat instability was detected by PCR amplification. Western blot analysis confirmed transgene expression in the brain. Southern blot analysis indicates a copy number of six. |