| First Author | Jhiang SM | Year | 1996 |
| Journal | Endocrinology | Volume | 137 |
| Issue | 1 | Pages | 375-8 |
| PubMed ID | 8536638 | Mgi Jnum | J:93679 |
| Mgi Id | MGI:3487359 | Doi | 10.1210/endo.137.1.8536638 |
| Citation | Jhiang SM, et al. (1996) Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology 137(1):375-8 |
| abstractText | The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to human papillary thyroid carcinomas, particularly in the nuclear cytologic features and the presence of local invasion. Our findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papillary thyroid carcinoma. |
