| Primary Identifier | MGI:5571850 | Allele Type | Targeted |
| Attribute String | Constitutively active | Gene | Ryr2 |
| Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 56 was replaced with one containing nucleotide substitutions that result in the amino acid substitution of aspartic acid for serine at position 2814 (S2814D). This mutation produces a constitutively active protein. The modified exon was followed by a floxed neo cassette that was removed by subsequent cre-mediated recombination. |
