| First Author | Jiang H | Year | 2016 |
| Journal | eNeuro | Volume | 3 |
| Issue | 4 | PubMed ID | 27622213 |
| Mgi Jnum | J:234906 | Mgi Id | MGI:5792170 |
| Doi | 10.1523/ENEURO.0183-16.2016 | Citation | Jiang H, et al. (2016) Adult Conditional Knockout of PGC-1alpha Leads to Loss of Dopamine Neurons. eNeuro 3(4):ENEURO.0183-16.2016 |
| abstractText | Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder. Recent studies have implicated a role for peroxisome proliferator-activated receptor gamma coactivator protein-1alpha (PGC-1alpha) in PD and in animal or cellular models of PD. The role of PGC-1alpha in the function and survival of substantia nigra pars compacta (SNpc) dopamine neurons is not clear. Here we find that there are four different PGC-1alpha isoforms expressed in SH-SY5Y cells, and these four isoforms are expressed across subregions of mouse brain. Adult conditional PGC-1alpha knock-out mice show a significant loss of dopaminergic neurons that is accompanied by a reduction of dopamine in the striatum. In human PD postmortem tissue from the SNpc, there is a reduction of PGC-1alpha isoforms and mitochondria markers. Our findings suggest that all four isoforms of PGC-1alpha are required for the proper expression of mitochondrial proteins in SNpc DA neurons and that PGC-1alpha is essential for SNpc DA neuronal survival, possibly through the maintenance of mitochondrial function. |
