Primary Identifier | MGI:5581436 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Lrrc8a |
Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 3 and part of the following intron were replaced with a floxed neomycin selection cassette which was subsequently removed by cre excision. Immunoblotting of thymocyte lysates and FACS analysis of splenic T and B cells confirmed the absence of protein expression in homozygous mutant mice. |