| First Author | López-Ortega O | Year | 2016 |
| Journal | Cytoskeleton (Hoboken) | Volume | 73 |
| Issue | 5 | Pages | 258-68 |
| PubMed ID | 27106882 | Mgi Jnum | J:312166 |
| Mgi Id | MGI:6783286 | Doi | 10.1002/cm.21299 |
| Citation | Lopez-Ortega O, et al. (2016) Myo1g is an active player in maintaining cell stiffness in B-lymphocytes. Cytoskeleton (Hoboken) 73(5):258-68 |
| abstractText | B-lymphocytes are migrating cells that specialize in antigen presentation, antibody secretion, and endocytosis; these processes implicate the modulation of plasma membrane elasticity. Cell stiffness is a force generated by the interaction between the actin-cytoskeleton and the plasma membrane, which requires the participation of several proteins. These proteins include class I myosins, which are now considered to play a role in controlling membrane-cytoskeleton interactions. In this study, we identified the motor protein Myosin 1g (Myo1g) as a mediator of this phenomenon. The absence of Myo1g decreased the cell stiffness, affecting cell adhesion, cell spreading, phagocytosis, and endocytosis in B-lymphocytes. The results described here reveal a novel molecular mechanism by which Myo1g mediates and regulates cell stiffness in B-lymphocytes. (c) 2016 Wiley Periodicals, Inc. |
