| First Author | Yang Y | Year | 2020 |
| Journal | Sichuan Da Xue Xue Bao Yi Xue Ban | Volume | 51 |
| Issue | 2 | Pages | 200-206 |
| PubMed ID | 32220188 | Mgi Jnum | J:289007 |
| Mgi Id | MGI:6435944 | Doi | 10.12182/20200360102 |
| Citation | Yang Y, et al. (2020) Pathophysiological Study on Thoracic Ascending Aorta of Mice with Myh11 (R247C) Heterozygous Mutation in Norepinephrine-induced Hypertension Model. Sichuan Da Xue Xue Bao Yi Xue Ban 51(2):200-206 |
| abstractText | Objevtive: To explore the thoracic ascending aortic TAA pathophysiological characteristics of heterozygous mutant Myh11 (R247C/+) mice under the norepinephrine-induced hypertension mode. Methods: Female heterozygous mutant Myh11 (R247C/+) and wild type Myh11 (+/+) mice were selected as experimental group (HET group) and control group (WT group)respectively. The hypertensive model was induced by intraperitoneal injection of norepinephrine (NE)and TAA diameter and invasive blood pressure (Bp) data were collected dynamically in real time using high-frequency ultrasound imaging and invasive arterial blood pressure monitoring techniqueso as to indirectly analyze TAA compliance of two groups of mice. At the same timethe incidences of hemothorax and TAA rupture were further analyzed by autopsy and histology. Results: After injection of NEheterozygous mice did not show a higher Bp increase percentage in systole or diastole comparing with wildtype mice. Howeverheterozygous mice exhibited 17% and 32% higher TAA diameter dilation percentage than wildtype ones in systole and diastole respectively. Two heterozygous mice had TAA dissection and ruptureand the incidence of hemothorax in heterozygous mice (3/5) was higher than that in wildtype (0/5). Conclusion: It was very likely that the altered TAA wall compliance of mutant Myh11 (R247C/+) mice had led to a higher TAA dilation degree than that in wildtypeand even could be the potential reason of TAA dissection and rupture. |
