| First Author | Kolb AF | Year | 2013 |
| Journal | Transgenic Res | Volume | 22 |
| Issue | 2 | Pages | 425-34 |
| PubMed ID | 22983824 | Mgi Jnum | J:212511 |
| Mgi Id | MGI:5581589 | Doi | 10.1007/s11248-012-9654-7 |
| Citation | Kolb AF, et al. (2013) Mammary gland development is delayed in mice deficient for aminopeptidase N. Transgenic Res 22(2):425-34 |
| abstractText | Development of the mammary gland requires the coordinated action of proteolytic enzymes during two phases of remodelling. Firstly, new ducts and side-branches thereof need to be established during pregnancy to generate an extensive ductal tree allowing the secretion and transport of milk. A second wave of remodelling occurs during mammary involution after weaning. We have analysed the role of the cell surface protease aminopeptidase N (Anpep, APN, CD13) during these processes using Anpep deficient and Anpep over-expressing mice. We find that APN deficiency significantly delays mammary gland morphogenesis during gestation. The defect is characterised by a reduction in alveolar buds and duct branching at mid-pregnancy. Conversely over-expression of Anpep leads to accelerated ductal development. This indicates that Anpep plays a critical role in the proteolytic remodelling of mammary tissue during adult mammary development. |
