| Primary Identifier | MGI:5607728 | Allele Type | Chemically induced (ENU) |
| Attribute String | Not Specified | Gene | Nlrp3 |
| Inheritance Mode | Dominant | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | Beutler Mutagenetix |
| molecularNote | The molecular lesion is an A to G transition at base pair 59,565,850 (v38) on chromosome 11, or base pair 24,282 in the GenBank genomic region NC_000077. This corresponds to nucleotide 3,063 in the mRNA sequence NM_145827, within exon 4 of 10 total exons. The mutation results in an aspartic acid (D) to glycine (G) substitution at position 946 (D946G) in the NLRP3 protein, and is strongly predicted by Polyphen-2 to be benign (score = 0.017). |
