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Allele : Scn1a<tm1.1Dsf> sodium channel, voltage-gated, type I, alpha; targeted mutation 1.1, Dravet Syndrome Foundation Spain

Primary Identifier  MGI:5615963 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, No functional change Gene  Scn1a
Transmission  Germline Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  A mini-gene cassette containing a loxP site, coding sequence for wild-type exon 26, bpA, an FRT-flanked neomycin cassette, and a second loxP site was introduced into intron 25 and a A1783V mutation was introduced into exon 26. The mutation results in a C to T change at nucleotide 5348 altering the corresponding amino acid from alanine to valine at position 1783.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Scn1a<A1783Vfl>,
  • Scn1a<A1783Vfl>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

26 Publication categories

Trail: Allele