| First Author | Neumann K | Year | 2014 |
| Journal | Immunity | Volume | 40 |
| Issue | 3 | Pages | 389-99 |
| PubMed ID | 24631154 | Mgi Jnum | J:210326 |
| Mgi Id | MGI:5570496 | Doi | 10.1016/j.immuni.2013.12.015 |
| Citation | Neumann K, et al. (2014) Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Immunity 40(3):389-99 |
| abstractText | Recognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood. Here, we identify the inhibitory C-type lectin receptor Clec12a as a specific receptor for dead cells. Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Clec12a inhibited inflammatory responses to MSU in vitro, and Clec12a-deficient mice exhibited hyperinflammatory responses after being challenged with MSU or necrotic cells and after radiation-induced thymocyte killing in vivo. Thus, we identified a negative regulatory MSU receptor that controls noninfectious inflammation in response to cell death that has implications for autoimmunity and inflammatory disease. |
