| First Author | Ohtani K | Year | 2013 |
| Journal | Circ Res | Volume | 113 |
| Issue | 7 | Pages | 856-62 |
| PubMed ID | 23856522 | Mgi Jnum | J:211228 |
| Mgi Id | MGI:5574281 | Doi | 10.1161/CIRCRESAHA.113.302035 |
| Citation | Ohtani K, et al. (2013) Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ Res 113(7):856-62 |
| abstractText | RATIONALE: The developmental role of the H3K27 demethylases Jmjd3, especially its epigenetic regulation at target genes in response to upstream developmental signaling, is unclear. OBJECTIVE: To determine the role of Jmjd3 during mesoderm and cardiovascular lineage commitment. METHODS AND RESULTS: Ablation of Jmjd3 in mouse embryonic stem cells does not affect the maintenance of pluripotency and self-renewal but compromised mesoderm and subsequent endothelial and cardiac differentiation. Jmjd3 reduces H3K27me3 marks at the Brachyury promoter and facilitates the recruitment of beta-catenin, which is critical for Wnt signal-induced mesoderm differentiation. CONCLUSIONS: These data demonstrate that Jmjd3 is required for mesoderm differentiation and cardiovascular lineage commitment. |
