| Primary Identifier | MGI:5621017 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Sod3 |
| Transmission | Germline | Strain of Origin | (C57BL/6NTac x 129S6/SvEvTac)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 2 was replaced with one in which a C to G mutation results in the amino acid substitution of arginine with glycine at position 242 (p.R242G on precursor or p.R227G on mature peptide). A loxP site was inserted into intron 1 and a loxP site flanked neomycin resistance gene cassette into intron 2. The mutation mimics a human SNP (p.R231G on precursor or p.R213G on mature peptide) that is associated with susceptibility to cardiovascular and lung disease. |
