| Primary Identifier | MGI:5621024 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Crx |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 4 was modified to contain a 2 base pair deletion in the transactivation domain (E168d2) linked to early onset severe autosomal dominant forms of cone-rod dystrophy (adCoRD) and Leber Congenital Amaurosis (adLCA). This mutation results in a frameshift and premature truncation of the expected product. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of exon 4. |
