| First Author | Carraway KL 3rd | Year | 2006 |
| Journal | Cancer Cell | Volume | 10 |
| Issue | 2 | Pages | 93-5 |
| PubMed ID | 16904607 | Mgi Jnum | J:112688 |
| Mgi Id | MGI:3663194 | Doi | 10.1016/j.ccr.2006.07.015 |
| Citation | Carraway KL 3rd, et al. (2006) Co-opted integrin signaling in ErbB2-induced mammary tumor progression. Cancer Cell 10(2):93-5 |
| abstractText | Although almost two decades of study point to a central role for aberrant ErbB2 activation in breast cancer, many cellular and biochemical mechanisms underlying ErbB2-induced tumor initiation and progression remain to be resolved. A study by Guo et al. published recently in Cell indicates that the signaling function of beta4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression. |
