| First Author | Lin F | Year | 2014 |
| Journal | Autophagy | Volume | 10 |
| Issue | 4 | Pages | 691-3 |
| PubMed ID | 24434795 | Mgi Jnum | J:220668 |
| Mgi Id | MGI:5635841 | Doi | 10.4161/auto.27749 |
| Citation | Lin F, et al. (2014) Seeing is believing: dynamic changes in renal epithelial autophagy during injury and repair. Autophagy 10(4):691-3 |
| abstractText | Ischemic injury to the kidneys is a prevalent clinical problem, contributing importantly to chronic kidney disease. Yet, underlying molecular mechanisms are elusive. To address the possible role of autophagy, we engineered a novel strain of mice harboring a ubiquitously expressed CAG-RFP-EGFP-LC3 transgene. Using this tool, we examined the post-ischemic kidney and detailed the dynamics of renal tubular epithelial autophagy. In addition, we defined the role of MTOR in the resolution of autophagy during epithelial survival and kidney repair. |
