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Allele : Col1a1<tm1.1(CAG-Sirt2)Jmi> collagen, type I, alpha 1; targeted mutation 1.1, Jeffrey Milbrandt
Primary Identifier  MGI:5636689 Allele Type  Targeted
Attribute String  Inserted expressed sequence Gene  Col1a1
Transmission  Germline Strain of Origin  (C57BL/6 x 129S4/SvJae)F1
Is Recombinase  false Is Wild Type  false
molecularNote  The SIRT2-Tg flox-STOP-flox construct was designed to insert (from 5' to 3') an FRT site, a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG; from the pCAGGS vector), a loxP-flanked transcriptional STOP cassette, the mouse sirtuin 2 (Sirt2) cDNA sequence, and a PGK-hygro-polyA sequence (with a second FRT site between the PGK and hygro) into the 3' UTR of the mouse collagen A1 (Col1a1) locus. Cre mediated recombination removed the floxed STOP construct.
  • mutations:
  • Insertion
  • synonyms:
  • SIRT2tg,
  • SIRT2tg
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

5 Publication categories

Trail: Allele




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