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Allele : Map3k8<tm2.1Sley> mitogen-activated protein kinase kinase kinase 8; targeted mutation 2.1, Steven C Ley
Primary Identifier  MGI:5636697 Allele Type  Targeted
Attribute String  Hypomorph Gene  Map3k8
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo cassette was inserted into intron 5 and an S400A mutation was inserted into exon 7 via homologous recombination. Cre mediated recombination removed the neo cassette. Mutant protein expression is similar to wild-type but activation of ERK-1/2 following LPS stimulation is blocked.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Map3k8<S400A>,
  • Map3k8<S400A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories

Trail: Allele




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