| First Author | Astori S | Year | 2013 |
| Journal | J Neurosci | Volume | 33 |
| Issue | 2 | Pages | 624-30 |
| PubMed ID | 23303941 | Mgi Jnum | J:318154 |
| Mgi Id | MGI:6858490 | Doi | 10.1523/JNEUROSCI.3185-12.2013 |
| Citation | Astori S, et al. (2013) Synaptic plasticity at intrathalamic connections via CaV3.3 T-type Ca2+ channels and GluN2B-containing NMDA receptors. J Neurosci 33(2):624-30 |
| abstractText | The T-type Ca(2+) channels encoded by the Ca(V)3 genes are well established electrogenic drivers for burst discharge. Here, using Ca(V)3.3(-/-) mice we found that Ca(V)3.3 channels trigger synaptic plasticity in reticular thalamic neurons. Burst discharge via Ca(V)3.3 channels induced long-term potentiation at thalamoreticular inputs when coactivated with GluN2B-containing NMDA receptors, which are the dominant subtype at these synapses. Notably, oscillatory burst discharge of reticular neurons is typical for sleep-related rhythms, suggesting that sleep contributes to strengthening intrathalamic circuits. |
