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Allele : App<tm3.1Tcs> amyloid beta precursor protein; targeted mutation 3.1, Takaomi C Saido
Primary Identifier  MGI:5637817 Allele Type  Targeted
Attribute String  Humanized sequence Gene  App
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  The sequence of exon 16 was humanized by the introduction of the Swedish mutations (p.KM670_671delinsNL) and exon 17 by the introduction of the Arctic (p.E693G) and Beyreuther/Iberian (p.I716F) mutations. A loxP site flanked neomycin resistance gene cassette was inserted in intron 16 and subsequently removed through Cre-mediated recombination.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • App<NL-G-F>,
  • App<NL-G-F>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

4 Carried By

Trail: Allele

0 Driven By

165 Publication categories

Trail: Allele




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