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Allele : Kras<tm3Bbd> Kirsten rat sarcoma viral oncogene homolog; targeted mutation 3, Mariano Barbacid

Primary Identifier  MGI:5645350 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Null/knockout Gene  Kras
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting vector was designed to insert a FRT site flanked neomycin resistance gene and STOP cassette upstream of the ATG initiation codon into intron 1 and glycine codon 12 (GGT) in exon 2 was changed to valine (GTA) (p.G12V), a mutation commonly found in human tumors.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Kras<FSFG12V>,
  • Kras<FSFG12V>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

12 Publication categories

Trail: Allele