| First Author | Qin Y | Year | 2014 |
| Journal | Liver Int | Volume | 34 |
| Issue | 4 | Pages | 567-75 |
| PubMed ID | 23998356 | Mgi Jnum | J:241119 |
| Mgi Id | MGI:5897746 | Doi | 10.1111/liv.12286 |
| Citation | Qin Y, et al. (2014) Ghrelin contributes to protection of hepatocellular injury induced by ischaemia/reperfusion. Liver Int 34(4):567-75 |
| abstractText | BACKGROUND & AIMS: Ghrelin, a gut hormone with pleiotropic effects, may act as a protective signal in parenchymal cells. We investigated the protective effects of ghrelin on hepatocytes after ischaemia/reperfusion (I/R). METHODS: Hepatic injury was assessed by measurement of plasma alanine aminotransferase (ALT) and lactate dehydrogenase (LDH), histological analysis, and TUNEL assay. Effects of exogenous ghrelin and ghrelin receptor gene deletion on I/R induced injury of liver were evaluated. RESULTS: Ischaemia/reperfusion induced a profound injury to hepatocytes. This was accompanied by elevations in plasma ALT and LDH. Pretreatment with ghrelin significantly reduced elevations in plasma ALT and LDH, and attenuated tissue damage induced by hepatic I/R in mice. Hepatic injury induced by I/R was more pronounced in ghrelin receptor gene null mice. Ghrelin administration blocked the up-regulation of AMP-activated protein kinase (AMPK) activity induced by hepatic I/R. CONCLUSIONS: This study demonstrates that ghrelin contributes to the cytoprotection during hepatic I/R. |
