| First Author | Bailey JS | Year | 2008 |
| Journal | Genes Brain Behav | Volume | 7 |
| Issue | 7 | Pages | 761-9 |
| PubMed ID | 19130624 | Mgi Jnum | J:151136 |
| Mgi Id | MGI:4352818 | Doi | 10.1111/j.1601-183x.2008.00415.x |
| Citation | Bailey JS, et al. (2008) Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains. Genes Brain Behav 7(7):761-9 |
| abstractText | We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open-field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open-field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open-field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors. |
