| First Author | Chen J | Year | 2017 |
| Journal | Cell Rep | Volume | 21 |
| Issue | 6 | Pages | 1588-1599 |
| PubMed ID | 29117563 | Mgi Jnum | J:254786 |
| Mgi Id | MGI:6103981 | Doi | 10.1016/j.celrep.2017.10.059 |
| Citation | Chen J, et al. (2017) Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action. Cell Rep 21(6):1588-1599 |
| abstractText | Zika virus (ZIKV) infection during pregnancy in humans results in intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we found that fetus-derived type I interferon (IFN-I) signaling can enhance anti-ZIKV responses and provide clinical benefits to the fetus. Because IFN-lambda shares signaling cascades and antiviral functions with IFN-I, we investigated the in vivo effects of IFN-lambda in ZIKV-infected pregnant mice. IFN-lambda administration during mid-pregnancy reduced ZIKV burden in maternal and fetal organs and alleviated placental injuries and fetal demise. In addition, prophylactic and therapeutic treatment of IFN-lambda1 in a human trophoblast line, as well as in primary human amniotic epithelial cells, greatly reduced the ZIKV burden. Our data highlight IFN-lambda1 as a potential therapeutic useful for women at risk for congenital Zika disease. |
