| Primary Identifier | MGI:5693835 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Tor1a |
| Transmission | Germline | Strain of Origin | 129S/SvEv x C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A targeting vector was designed to insert a loxP site upstream of exon 5 followed by a FRT-flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 5 of the gene. A mutant exon 5, with a glutamic acid residue deletion, was inserted downstream of the neo cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed the wild-type exon 5 and allows expression of mutant exon 5. |
