| Primary Identifier | MGI:5696351 | Allele Type | Chemically induced (ENU) |
| Gene | Dnah11 | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | B2B/CvDC |
| description | Summative Diagnosis: Cardiovascular phenotypes: Situs inversus with mirror image dextrocardia Noncardiovascular phenotype: Immotile cilia in the tracheal airway epithelia Phenotypic Similarity to Human Syndrome: Primary ciliary dyskinesia Kartagener's syndrome |
| molecularNote | This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1468Clo. The molecular lesion for this subline is attributed to an A to G substitution at coding nucleotide position 5966 in exon 35 of the cDNA (c.5966A>G, NM_010060). This changes the asparagine residue to serine at position 1989 of the encoded protein (p.N1989S). |
