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Allele : Tg(CAG-Bgeo,-MYC)1Saa transgene insertion 1, Sarki A Abdulkadir
Primary Identifier  MGI:5695550 Allele Type  Transgenic
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter Gene  Tg(CAG-Bgeo,-MYC)1Saa
Strain of Origin  129S/SvEv Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene contains from 5' to 3', the CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter, a loxP-flanked STOP cassette (beta-galactosidase/neomycin resistance cassette [beta-geo] with three copies of the SV40 polyA termination signal) and the 1.8 kbp human myelocytomatosis oncogene cDNA sequence (MYC; including exons 2 and 3 and polyA site). The 10.8 kbp transgene was linearized and transfected into 129S/SvEv-derived embryonic stem (ES) cells. An ES cell clone with a single-copy transgene integration was selected for injection into blastocysts. Constitutive beta-galactosidase (lacZ) expression is directed to multiple tissue types. Removal of the STOP cassette by Cre-mediated recombination results in removal of lacZ and expression of MYC.
  • mutations:
  • Insertion
  • synonyms:
  • Z-MYC,
  • Z-MYC
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1 Feature

Trail: Allele

Genome

1 Expresses

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0 Mutation Involves

Phenotype

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5 Publication categories

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