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Allele : Ppox<tm1Had> protoporphyrinogen oxidase; targeted mutation 1, Harry A Dailey

Primary Identifier  MGI:5696597 Allele Type  Targeted
Attribute String  Humanized sequence, Hypomorph Gene  Ppox
Inheritance Mode  Semidominant Transmission  Germline
Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+> Is Recombinase  false
Is Wild Type  false
molecularNote  A single codon was mutagenized to replace the arginine at amino acid 59 with tryptophan, mimicking the predominant variegate porphyria mutation in the South African human population, and a loxP flanked neomycin selection cassette was inserted into intron 2.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • R59W/Neo,
  • R59W/Neo
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele