| First Author | Behan DP | Year | 1993 |
| Journal | Genomics | Volume | 16 |
| Issue | 1 | Pages | 63-8 |
| PubMed ID | 8198617 | Mgi Jnum | J:23179 |
| Mgi Id | MGI:71355 | Doi | 10.1006/geno.1993.1141 |
| Citation | Behan DP, et al. (1993) Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP) [published erratum appears in Genomics 1994 Jan 1;19(1):198]. Genomics 16(1):63-8 |
| abstractText | The human CRF-binding protein gene has been cloned and mapped to the distal region of chromosome 13 and loci 5q in the mouse and human genomes, respectively. The gene consists of 7 exons and 6 introns. The mature protein has 10 cysteines and 5 tandem disulfide bridges 4 of which are contained within exons 3, 5, 6, and 7. One bridge is shared by exons 3 and 4. The signal peptide and the first 3 amino acids of the mature protein were coded for by an extreme 5' exon. Primer extension analyses revealed the transcriptional initiation site to be located 32 bp downstream from a consensus TATA box. The promoter sequence contained a number of putative promoter elements including an AP-1 site, three ER-half sites, the immunoglobulin enhancer elements NF-kappa B and INF-1, and the liver-specific enhancers LFA1 and LFB1. |
