| First Author | Manenti G | Year | 1997 |
| Journal | Mamm Genome | Volume | 8 |
| Issue | 11 | Pages | 801-4 |
| PubMed ID | 9337390 | Mgi Jnum | J:44025 |
| Mgi Id | MGI:1099276 | Doi | 10.1007/s003359900582 |
| Citation | Manenti G, et al. (1997) Pas1 is a common lung cancer susceptibility locus in three mouse strains. Mamm Genome 8(11):801-4 |
| abstractText | Inherited predisposition to lung cancer is a phenotypic trait shared by different mouse inbred strains that show either a high or an intermediate predisposition. Other strains are instead genetically resistant. The Pas1 locus is the major determinant of lung cancer predisposition in the A/J strain (Gariboldi et al. 1993). To define the determinants of susceptibility to lung tumorigenesis in the highly susceptible SWR/J and in the intermediately susceptible BALB/c mice, we analyzed (BALB/c x SWR/J)F2 and (BALB/c x C3H/He)F2 crosses by genetic linkage experiments. The present results provide unequivocal evidence that the same Pas1/+ allele that leads to lung cancer predisposition is shared by A/J, SWR/J, and BALB/c strains. The intermediate susceptibility of the BALB/c strain would result by interaction of Pas1 locus with lung cancer resistance loci. |
