| Primary Identifier | MGI:5700375 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Alk |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Hypogonadotropic Hypogonadism in male homozygotes (J:226955) |
| molecularNote | A NLS-lacZ-polyA cassette was inserted into intron 19. It was flanked on the 5'end with a single FRT site and on the 3' end with a single loxP site. An additional loxP site followed by another FRT site was inserted into intron 23. Flp-mediated recombination in ES cells deleted the expression cassette and exons 20-23 (i.e. the kinase domain encoding exons). Western blot confirmed that no detectable protein is expressed from this allele. |
