| First Author | Ferguson BS | Year | 2021 |
| Journal | Am J Physiol Heart Circ Physiol | Volume | 321 |
| Issue | 2 | Pages | H382-H389 |
| PubMed ID | 34142888 | Mgi Jnum | J:311875 |
| Mgi Id | MGI:6720960 | Doi | 10.1152/ajpheart.00115.2021 |
| Citation | Ferguson BS, et al. (2021) DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy. Am J Physiol Heart Circ Physiol |
| abstractText | Dual-specificity phosphatases (DUSPs) serve critical roles in the regulation of mitogen-activated protein kinases, but their functions in the cardiovascular system remain poorly defined. Here, we provide evidence that DUSP5, which resides in the nucleus and specifically dephosphorylates extracellular signal-regulated kinase (ERK1/2), blocks pulmonary vascular smooth muscle cell proliferation. In response to angiotensin II infusion, mice lacking DUSP5 develop pulmonary hypertension and right ventricular cardiac hypertrophy. The findings illustrate DUSP5-mediated suppression of ERK signaling in the lungs as a protective mechanism. |
