| First Author | Kinsey-Jones JS | Year | 2015 |
| Journal | Obesity (Silver Spring) | Volume | 23 |
| Issue | 6 | Pages | 1194-200 |
| PubMed ID | 25958858 | Mgi Jnum | J:233468 |
| Mgi Id | MGI:5784808 | Doi | 10.1002/oby.21083 |
| Citation | Kinsey-Jones JS, et al. (2015) GPRC6a is not required for the effects of a high-protein diet on body weight in mice. Obesity (Silver Spring) 23(6):1194-200 |
| abstractText | OBJECTIVE: The G-protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low- and high-protein diets on body weight and food intake in mice. METHODS: The role of GPRC6A in mediating the effects of a low-protein diet on body weight was investigated in GPRC6a knockout (GPRC6a-KO) and wild-type (WT) mice fed a control diet (18% protein) or a low-protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high-protein diet on body weight was investigated in GPRC6a-KO and WT mice fed a control diet (18% protein) or a high-protein diet (50% protein) for 5 weeks. RESULTS: A high-protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a-KO mice. A low-protein diet decreased body weight gain in GPRC6a-KO mice. CONCLUSIONS: GPRC6A was not necessary for the effects of a low- or high-protein diet on body weight and likely does not play a role in protein-induced satiety. |
