| Primary Identifier | MGI:5708157 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Atxn3 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A genomic region including exons 7-11 was replaced with a human cDNA containing exons 7 - 11. The cDNA was derived from the GM06153 line of human fibroblasts containing 69 CAG repeats which expanded to 91 repeats during the targeting process. An FRT flanked neo cassette was inserted upstream of the cDNA. Flp mediated recombination removed the neo cassette. Mild intergenerational instability of CAG repeats is present in both maternal and paternal transmission. Upon maternal transmission, the CAG tract shows a tendency toward contraction, while upon paternal transmission, the CAG tract shows a tendency toward expansion. |
