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Allele : Nefl<tm1.1Liem> neurofilament, light polypeptide; targeted mutation 1.1, Ronald KH Liem
Primary Identifier  MGI:5749796 Allele Type  Targeted
Attribute String  Hypomorph Gene  Nefl
Transmission  Germline Strain of Origin  (C57BL/6J x 129S6/SvEvTac)F1
Is Recombinase  false Is Wild Type  false
molecularNote  A P8R (CCG>CGG> mutation was inserted in exon 1 and a floxed neo cassette was inserted in intron 1 via homologous recombination. Cre mediated recombination removed the neo cassette. Protein levels are decreased 50-60% in the brains and spinal cords of homozygous mice compared to wild-type controls.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Nefl<P8R>,
  • Nefl<P8R>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Carried By

Trail: Allele

0 Driven By

4 Publication categories

Trail: Allele




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