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Allele : Runx2<tm1.1Hkiy> runt related transcription factor 2; targeted mutation 1.1, Hiroshi Kiyono
Primary Identifier  MGI:5750985 Allele Type  Targeted
Attribute String  Modified isoform(s) Gene  Runx2
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  The I isoform-specific translation initiation site in exon 2 was replaced with a stop codon (TGA) and a floxed neomycin resistance cassette inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette. RT-PCR analysis confirmed that total and variant transcript expression levels are restored in calvarial cells from E18.5 homozygous mutant mice.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Runx2-I<TGA>,
  • Runx2-I<TGA>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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