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Allele : Nhs<em1(IMPC)Tcp> NHS actin remodeling regulator; endonuclease-mediated mutation 1, The Centre for Phenogenomics

Primary Identifier  MGI:5754996 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Nhs
Strain of Origin  C57BL/6NCrl Is Recombinase  false
Is Wild Type  false Project Collection  IMPC
molecularNote  This allele produced from project TCPR0257 at TCP by injecting Cas9 mRNA and two guide RNAs with the spacer sequences ACATCTTCCTCCCAGCGACC and CTTGCTCTCGATGTCCAAGT. This resulted in a 77 bp deletion from ChrX:161875305 to 161875381 in ENSMUSE00000470130. This mutation is predicted to cause a frameshift with amino acid changes after residue 190 and early truncation 19 amino acids later (p.L190Qfs*21). (GRCm38).
  • mutations:
  • Intragenic deletion,
  • Insertion
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele