| Primary Identifier | MGI:5754842 | Allele Type | Spontaneous |
| Attribute String | Null/knockout | Gene | Grm6 |
| Inheritance Mode | Recessive | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | This spontaneous G-to-A point transition at the last position in exon 8 affects splice donor G-GT by changing it to A-GT. This results in the use of a cryptic splice donor A-GT 28 bp downstream. The resulting 3' extension of exon 8 by 28 bp results in a frameshift. Immunohistochemistry does not detect this protein in the dendritic tips of depolarizing bipolar cells in the retina indicating that this is a null allele. |
