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Allele : Lrrk2<tm1.1Adre> leucine-rich repeat kinase 2; targeted mutation 1.1, Alastair D Reith
Primary Identifier  MGI:5759912 Allele Type  Targeted
Gene  Lrrk2 Transmission  Germline
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  A targeting vector was designed to introduce a glycine to serine (G2019S) substitution at base pair 107/8 (GG to GC) in exon 41. An FRT-flanked neomycin cassette was introduced into exon 41. LoxP site are also included in the vector although the location is not specified. FLP recombinase mediated recombination removed the neo cassette.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • LRRK2-G2019S<GSK>,
  • LRRK2-G2019S<GSK>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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6 Publication categories

Trail: Allele




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