| Primary Identifier | MGI:5763014 | Allele Type | Targeted |
| Attribute String | Conditional ready, Hypomorph | Gene | Acvr1 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 5 and associated intronic sequence is replaced with a loxP site, the corresponding wild-type human exon 5 and associated intronic sequence, Lox2372 site, inverted exon 5 with a nucleotide substitution that results in the amino acid substitution of histidine for arginine at position 206 (R206H), loxP site, a small insert derived from rabbit hemoglobin beta intron 2, lox2372 site and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. The R206H point mutation mimics one identified in humans as causing Fibrodysplasia Ossificans Progressiva (FOP). Prior to cre-mediated half of its transcripts lacked exon 5 resulting in a hypomorphic allele. |
