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Allele : Tg(CAG-HSPB1)HPks transgene insertion H, Nick Parkinson
Primary Identifier  MGI:5775094 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(CAG-HSPB1)HPks
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene comprises the coding sequence for wild-type human heat shock protein family B (small) member 1 (HSPB1) downstream of the "CAG promoter" -- which consists of the cytomegalovirus immediate early (CMV-EI) enhancer followed by a 1.3-kb DNA segment including the promoter, first exon and first intron of the chicken beta-actin gene, with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene -- and followed by the rabbit beta-hemoglobin polyadenylation signal and 3' flanking sequence. Heterozygous mice of this high copy number line carry approximately 35 copies of the transgene.
  • mutations:
  • Insertion
  • synonyms:
  • HSP27 WT High copy line,
  • PCAGGS-HSP27-WT-HIGH-COPY,
  • chk.actin-HSP27 (WT),
  • chk.actin-HSP27 (WT),
  • PCAGGS-HSP27-WT-HIGH-COPY,
  • HSP27 WT High copy line
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0 Mutation Involves

Phenotype

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