| First Author | Sakai K | Year | 2016 |
| Journal | Sci Rep | Volume | 6 |
| Pages | 28636 | PubMed ID | 27346785 |
| Mgi Jnum | J:301955 | Mgi Id | MGI:6217816 |
| Doi | 10.1038/srep28636 | Citation | Sakai K, et al. (2016) Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders. Sci Rep 6:28636 |
| abstractText | The secreted glycoprotein Reelin is believed to play critical roles in the pathogenesis of several neuropsychiatric disorders. The highly basic C-terminal region (CTR) of Reelin is necessary for efficient activation of its downstream signaling, and the brain structure of knock-in mice that lack the CTR (DeltaC-KI mice) is impaired. Here, we performed a comprehensive behavioral test battery on DeltaC-KI mice, in order to evaluate the effects of partial loss-of-function of Reelin on brain functions. The DeltaC-KI mice were hyperactive and exhibited reduced anxiety-like and social behaviors. The working memory in DeltaC-KI mice was impaired in a T-maze test. There was little difference in spatial reference memory, depression-like behavior, prepulse inhibition, or fear memory between DeltaC-KI and wild-type mice. These results suggest that CTR-dependent Reelin functions are required for some specific normal brain functions and that DeltaC-KI mice recapitulate some aspects of neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder. |
