| First Author | Huang Z | Year | 2022 |
| Journal | Sci Adv | Volume | 8 |
| Issue | 23 | Pages | eabn5345 |
| PubMed ID | 35675406 | Mgi Jnum | J:326126 |
| Mgi Id | MGI:7293798 | Doi | 10.1126/sciadv.abn5345 |
| Citation | Huang Z, et al. (2022) Glucose-sensing glucagon-like peptide-1 receptor neurons in the dorsomedial hypothalamus regulate glucose metabolism. Sci Adv 8(23):eabn5345 |
| abstractText | Glucagon-like peptide-1 (GLP-1) regulates energy homeostasis via activation of the GLP-1 receptors (GLP-1Rs) in the central nervous system. However, the mechanism by which the central GLP-1 signal controls blood glucose levels, especially in different nutrient states, remains unclear. Here, we defined a population of glucose-sensing GLP-1R neurons in the dorsomedial hypothalamic nucleus (DMH), by which endogenous GLP-1 decreases glucose levels via the cross-talk between the hypothalamus and pancreas. Specifically, we illustrated the sufficiency and necessity of DMH(GLP-1R) in glucose regulation. The activation of the DMH(GLP-1R) neurons is mediated by a cAMP-PKA-dependent inhibition of a delayed rectifier potassium current. We also dissected a descending control of DMH(GLP-1R) -dorsal motor nucleus of the vagus nerve (DMV)-pancreas activity that can regulate glucose levels by increasing insulin release. Thus, our results illustrate how central GLP-1 action in the DMH can induce a nutrient state-dependent reduction in blood glucose level. |
