| Primary Identifier | MGI:7562553 | Allele Type | Endonuclease-mediated |
| Attribute String | Constitutively active, Humanized sequence | Gene | Stat3 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Lysine codon 392 (AAA) in exon 13 was changed to arginine (AGA) (p.K392R) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation, in the DNA-binding domain of the encoded peptide, represents the same human gain-of-function mutation (NM_011486.3:c.1175A>G) that affects diabetes severity. |
