| First Author | Prola A | Year | 2021 |
| Journal | Sci Adv | Volume | 7 |
| Issue | 1 | PubMed ID | 33523852 |
| Mgi Jnum | J:314750 | Mgi Id | MGI:6827270 |
| Doi | 10.1126/sciadv.abd6322 | Citation | Prola A, et al. (2021) Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle. Sci Adv 7(1) |
| abstractText | Unbalanced energy partitioning participates in the rise of obesity, a major public health concern in many countries. Increasing basal energy expenditure has been proposed as a strategy to fight obesity yet raises efficiency and safety concerns. Here, we show that mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis display increased basal energy expenditure and protection against high-fat diet-induced obesity. Mechanistically, muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of the inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and adenosine 5'-triphosphate (ATP) synthase, which was restored by cardiolipin enrichment. Our study reveals that selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level. |
